CAR-T Therapy

What is CAR-T Therapy?

CAR-T, which is the abbreviated form of chimeric antigen receptor T cell, is a special type of immune cell that has been genetically modified to exhibit a receptor to attach to cancer cells in the body. Chimeric means that the therapy will utilize both the functions of the T cell from the patient and the antigen that will be inserted into the cell.

Why is it important?

Other types of therapies to cure cancer include chemotherapy and radiation therapy. Chemotherapy treats patients with drugs that not only harm the cancer cells but also other healthy cells in the body. Radiation therapy harms other healthy cells in the body as well. On the other hand, CAR-T therapy is more target-oriented. Less number of healthy cells are under danger from such therapy. Moreover, the T cells are taken from patient. Therefore, there are less immune rejection response when the cells are injected back into the patient.

Activity Overview

The activity will provide a chance for students to learn about how Chimeric Antigen Receptor T-cell (CAR-T) therapy works. Through the activity, they will be able to layout all the steps involved in this therapy.

  • Duration: 20 min

  • Materials: worksheet

Class Materials

Below are links to download:

CAR-T Therapy Info Sheet

CAR-T Therapy Activity Sheet

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Dawon Chung 

Yoon Seo Kim

Se Yoon Park